A positive Pre-Hepatitis B S1 antigen indicates infection with the hepatitis B virus. Hepatitis B pre-S1 antigen is found on the surface protein of the hepatitis B virus, and is often used as an early detection of the hepatitis B virus because it is sensitive and a positive test indicates early infection with the hepatitis B virus. Clinically, pre-S1 antigen is often used in conjunction with the Hepatitis B 5 test for reference and comparison, for the detection of the disease in patients and for the detection of the effect of treatment. Therefore, if hepatitis B pre-S1 antigen is found to be positive, we should actively cooperate with the doctor to improve the relevant examinations and judge the condition, we should not judge the condition on our own based on a single result, and we should cooperate with the doctor for active treatment after clear diagnosis, so as to prevent the delay of the condition.