Blood creatinine 400μmol/L can still be recovered, according to the patient’s different causes, some patients can recover, some patients can not recover, as follows: 1, can recover: the patient’s disease is relatively short, is caused by various causes of acute renal insufficiency, for the cause of the patient to remove the cause of treatment, to improve kidney function and symptomatic treatment, the patient’s blood creatinine and reduce the 2. Non-recoverable: some patients have chronic kidney disease, and after many years, the blood creatinine exceeds the normal value, even reaching more than 400μmol/L. The possibility of recovering the blood creatinine of such patients is very small, and they even need hemodialysis and kidney transplantation treatment in the future. Therefore, the degree of recovery varies according to the cause of the patient’s disease.