The benefit of taking Trazodone at night is that it improves nighttime sleep and is less likely to cause excessive daytime sedation the next day.
Trazodone blocks 5 hydroxytryptamine reuptake, increases the concentration of 55 hydroxytryptamine in the synaptic gap, and stimulates 5 hydroxytryptamine 1A receptors to produce antidepressant and anxiolytic effects. At the same time, trazodone can antagonize the receptors on γ-aminobutyric acidergic interneurons, increase GABAergic effects, promote sleep, and increase slow-wave sleep. It has the effect of treating insomnia, anxiety and depression.
Trazodone half-life is shorter (initial phase 3-6 hours, slow phase 5-9 hours) characteristics of the evening dose can help improve night sleep, sleep aids faster onset of action; at the same time less likely to cause excessive sedation the next day.
Adverse effects of trazodone include drowsiness, fatigue, dizziness, headache, insomnia, nervousness, and constipation. It is contraindicated in cases of hypersensitivity to trazodone, severe hepatic or renal impairment, severe cardiac disease and impaired consciousness. Use with caution in lactating women, pregnant women, and children. Use with caution in patients with epilepsy, cardiac infarction, hepatic and renal insufficiency.
Please follow the doctor’s instructions for the use of medication.