There are many clinical implications of high urine protein. A daily urine protein quantification of more than 150 mg can be called proteinuria. Proteinuria has physiological proteinuria, which is usually caused by emergency situations such as strenuous exercise, fever, and stress. When the glomerular filtration membrane is damaged and permeability is increased, small, medium and large molecules of protein are produced in the urine and are leaked out, as in glomerulonephritis. When renal tubular structure or function is damaged, there is impaired reabsorption of filtered small molecule proteins so that small molecule proteins are lost to the urine, as in tubular acidosis. In addition, increased small molecular weight proteins such as hemoglobin and myoglobin in the blood can also result in proteinuria, as seen in diseases such as multiple myeloma.