Skin dark spot is mainly caused by the increase in the number of melanocytes and the increase in the volume of pigment in the intersection of the dermis and epidermis, which leads to the pigmentation in the limited area, and it can be adjusted by using oral medication with topical medication, and it can also be removed by physical therapy.1, oral medication: it is recommended to use vitamin C with vitamin E capsule, and it can be chosen to reduce the type of glutathione.2, topical medication Hydroquinone cream and vitamin E cream are recommended. Hydroquinone cream can effectively reduce the number and size of subcutaneous pigment cells, thus achieving whitening effect. Vitamin E cream is a strong antioxidant substance, which can fight against free radicals to whiten the skin and get rid of pigmentation.3. Physical therapy: It is recommended to choose to use picosecond laser or Q1064 laser to reduce the content of local pigment cells, and it can also directly crush subcutaneous pigment cells.