Hypothalamic dysfunction causes anovulation due to a decrease in gonadotropin-releasing hormone as a result of abnormal input signals from the hypothalamus. It occurs in young women and is most commonly associated with psychogenic hypogonadotropic amenorrhea. Various abnormal stimuli including sudden mental stimulation, strenuous exercise, excessive panic, depression, mental stress, and eagerly awaiting a child lead to amenorrhea. Psychogenic anorexia, simple weight loss amenorrhea and excessive exercise can also lead to endocrine disorders; severe systemic wasting diseases or malnutrition can also cause anovulation and amenorrhea. It is characterized by abnormal secretion of GnRH pulses from the hypothalamus directly and indirectly, resulting in abnormal secretion of pituitary glandular hormones, decreased levels of FSH and LH, and disappearance of LH peaks, resulting in anovulation. 1. Kallman syndrome: a genetic disorder with low gonadotropins and sex hormones, accompanied by hyposmia or absence of olfaction. The main manifestations are primary amenorrhea, no development of sexual characteristics when reaching pubertal age, normal karyotype, normal differentiation of ovaries and female internal genitalia, low gonadotropin levels, low estrogen and progesterone levels, and no functional activity of ovaries. 2.Anorexia nervosa: It is a psychoneuroendocrine disorder. Clinical manifestations are amenorrhea with varying degrees of hypogonadism, shrinking of the uterus and ovaries, and significant wasting. 3, systemic diseases: such as severe malnutrition, excessive obesity, lack of vitamins A, B and E in the diet can affect ovarian function, endocrine metabolic diseases, such as hyper- or hypo-thyroidism, severe diabetes mellitus can affect ovarian function and lead to anovulation. 4. Luteal insufficiency or luteal insufficiency: caused by insufficient amount or short duration of progesterone secretion from the ovarian corpus luteum. Treatment of this type of ovulation disorder involves psychiatric treatment and lifestyle modification to restore hypothalamic-pituitary-ovarian function. Because of its low gonadotropin profile, gonadotropin therapy can be applied to induce ovulation in those who require fertility .