According to the Technical Guidelines for Neocoronavirus Vaccination (First Edition), vaccination is prohibited for people with uncontrolled epilepsy and other serious neurological disorders (e.g., transverse myelitis, Guillain-Barre Syndrome, and demyelinating diseases). Therefore, the new crown vaccine cannot be given for brain white matter demyelinating diseases. Lesions of demyelination of the white matter of the brain present with acute neurological symptoms. For example, the patient develops clinical symptoms such as obvious dizziness, a feeling of drowsiness in the head, memory loss, difficulty in swallowing, etc. Some patients even develop paralysis of the limbs and urinary incontinence. It is usually not suitable for the new crown vaccine. If patients with white matter demyelinating lesions of the brain are combined with other serious allergic diseases or other serious related diseases, they are also not suitable for vaccination. Guidelines suggest that the new crown vaccine is not currently recommended for this disease, regardless of disease control.