When a patient has headache with loss of appetite, the common cause is plant nerve dysfunction, where the patient’s brain does not get enough rest due to insomnia and dreaminess, resulting in headache due to ischemia and lack of oxygen in the brain, and the patient also shows gastrointestinal symptoms, such as loss of appetite, nausea, belching, acid reflux and other indigestion symptoms. Headache with loss of appetite is often seen in clinical cases of infectious diseases, such as upper respiratory tract infections or infections in other parts of the body, which cause infectious headache due to the action of bacterial toxins. Due to the inflammatory stimulation of the organism caused by the action of toxins, patients experience a decrease in appetite. Patients are advised to have routine blood tests and acute reactive protein tests to observe whether there is an inflammatory response.