Treatment for pyriformis syndrome includes medication, injections, physical therapy and surgery. Piriformis syndrome is a condition in which the sciatic nerve is compressed by the piriformis muscle, causing poor local blood circulation and aseptic inflammation of the piriformis muscle, leading to symptoms of numbness, pain and limited movement in the area innervated by the sciatic nerve. Non-steroidal anti-inflammatory drugs as well as proprietary Chinese medicines that invigorate blood circulation and promote local blood circulation can effectively relieve the symptoms. Glucocorticosteroids have powerful anti-inflammatory effects. Injection of local anesthetic and glucocorticosteroids at the site of pyriformis syndrome can effectively reduce the aseptic inflammation of the sciatic nerve. The use of medications should be in accordance with the doctor’s instructions. Tui na massage and infrared radiation can reduce the neurologic symptoms of the sciatic nerve. Piriformis syndrome that does not respond to conservative treatment can also be treated with surgery, in which the compression of the sciatic nerve is relieved. Patients with pyriformis syndrome are advised to go to the hospital in time for a complete examination to determine the cause of the disease and then give targeted treatment or therapy.