Ultrasound normal gallbladder area uncomfortable, may be the gallbladder non-organic functional changes due to; may also be gastrointestinal, liver and other diseases caused. 1. Certain functional changes of the gallbladder: such as mild obstruction of the biliary tract, gallbladder spasm and other transient abnormalities of the biliary system, even including the early stage of mild cholecystitis, ultrasound examination may still be basically normal, and no abnormal changes of organic lesions can be detected, but pain, discomfort and other symptoms may occur. 2. Gastrointestinal and liver diseases and other non-gallbladder factors: certain gastrointestinal diseases such as gastritis, gastric ulcer, duodenal ulcer, liver diseases such as hepatitis, tumors, etc., may have symptoms of pain and discomfort in the gallbladder area, which need to be distinguished from gallbladder diseases. Gallbladder area discomfort generally need further examination to determine the nature, whether the need for treatment, etc., do not because of ultrasound normal delay.