Newborns with eye droppings that are yellow and pus-like in one eye may be due to congenital tear duct obstruction, impaction or conjunctivitis. 1. Congenital tear duct obstruction: Congenital tear duct obstruction, most common in newborns, may be accompanied by neonatal dacryocystitis, which manifests itself as persistent tearing, increased secretions, accumulation, and secondary infections, resulting in yellow pus-like eye droppings in one eye. 2. Inverted eyelashes: As the eyelashes of the corners of the eyes of newborns grow inward, they may irritate the cornea, resulting in inflammation of the eye, manifesting as yellow pus-like eye droppings in one eye, accompanied by tearing. 3. Conjunctivitis: If a newborn baby has yellow pus-like eye droppings in one eye, it is considered to be caused by conjunctivitis, which is mainly due to chlamydia and other infections, and may be accompanied by tears in the eyes while the eye secretions increase. If a newborn baby has yellow pus in one eye, it is recommended to consult a doctor for symptomatic intervention.