Itchy and ulcerated toes may be related to trauma, mosquito bites, localized airlessness, vesiculobullous foot odor, eczema, etc. Localized airlessness can be relieved by applying glyphosate lotion, fungal infections can be treated by applying ketoconazole ointment, etc., and eczema can be treated by applying dexamethasone acetate cream and other medications. 1. Trauma: If the toe area is traumatized and bumped, it may lead to skin ulceration. You need to clean and dress the wound in time, take cefixime and amoxicillin anti-inflammatory drugs orally, and apply mupirocin cream externally. 2. Mosquito bites: If there are mosquito bites, may cause local itching of the skin, scratching may be localized ulceration. You can apply local glycerine lotion, erythromycin ointment and other medications. 3. Local airlessness: For a long time without changing shoes or socks or shoes, it will lead to local airlessness, causing itchy and ulcerated toes. Generally do not need special treatment, keep feet dry and breathable, a period of time can be relieved by themselves. 4. Vesicular foot odor: patients with vesicular foot odor, itching and ulceration are typical symptoms. Ketoconazole ointment can be applied, ketoconazole ointment has antifungal effect. 5. Eczema: Eczema patients have obvious itching symptoms, scratching will have localized ulceration. Dexamethasone acetate cream can be applied to relieve, can also be applied to mometasone furoate cream and other hormonal drugs to relieve. 6. Dermatitis: dermatitis patients have obvious local itching, repeated scratching, local skin ulceration. Can be applied locally zinc oxide ointment, mupirocin ointment, erythromycin ointment and other drugs to relieve symptoms. It is recommended that patients with itchy and ulcerated toes consult a doctor in a timely manner to clarify the cause of the disease, the drug needs to be used in accordance with the doctor’s instructions, not indiscriminate use of drugs.