Vitamin A cream and azelaic acid both have the role of the treatment of acne vulgaris, but the specific main treatment is slightly different, can not be compared, symptomatic selection of suitable drugs can be. 1. Vitamin A cream is mainly used to assist in the treatment of psoriasis, keratosis follicularis, furunculosis, mucous membrane leukoplakia, flat warts, acne vulgaris, adverse reactions include skin irritation, pregnant women in the first trimester of pregnancy, breastfeeding women, allergic to the product is contraindicated, the product can not be used in the eye. 2. azelaic acid is also a common dosage form of cream, mainly used for the local treatment of mild to moderate inflammatory acne vulgaris, adverse reactions include itching, flaking, rash, etc., patients allergic to the product is prohibited. It is recommended that patients who are unwell go to a regular hospital in time and follow the doctor’s instructions for symptomatic treatment.