A person’s beauty is not only expressed in the aspects of good looks, good face, tall, and outstanding temperament, but the lack of any one part of the body will have an imperfect effect on the overall image. The human skull consists of 23 bones, and its role is mainly to support and protect the brain and other important organs. When a skull defect occurs due to something unexpected in life, it needs to be repaired accordingly. Cranioplasty is a common brain surgery for repairing skull defects caused by traumatic brain injury and craniotomy. The purpose of cranioplasty is to solve the problems such as the inability to protect the brain tissue due to the presence of defective area, the obstacle of blood supply, and the abnormality of cerebrospinal fluid circulation, as well as to solve the problem of appearance repair. The key to cranial bone repair is the choice of material, which varies in price and produces very different results. Although titanium mesh is widely used in the clinic, titanium mesh as a metal material is not an ideal choice for patients in terms of biocompatibility. If the incision heals poorly, it is easy to cause damage to the scalp tissue and expose the titanium mesh, and because of its fast heat transfer, it can increase the sensitivity of the patient’s head to hot and cold stimuli, resulting in pain. We use PEEK material for cranial bone repair surgery, the clinical effect is remarkable, by the patient’s good feedback. Polyether ether ketone or PEEK material has become an effective repair of cranial defects of a material, all the properties are very good, very good to overcome the many shortcomings of the titanium mesh, based on the three-dimensional reconstruction, and the defective area of the anastomosis for the perfect molding, and re-establishment of the overall structure of the skull, is a patient’s can rest assured that the choice of a good material.