Tuberculosis pleural effusion is definitely contagious, and tuberculosis pleural effusion contains a very high concentration of a large number of Mycobacterium tuberculosis. Mycobacterium tuberculosis is a very contagious pathogen that easily invades the mucosa of lung tissue, causing it to develop significant congestion, edema, adhesions, and a large amount of inflammatory secretions to ooze out, resulting in varying degrees of fibrosis, calcification, and even cavernous formation of lung tissue. Excessive accumulation of inflammatory secretions can lead to pleurisy, causing pleural effusion, and the high concentration of Mycobacterium tuberculosis inside is obviously infectious. It usually compresses the lung tissue, which leads to symptoms of respiratory distress such as wheezing, shortness of breath and chest tightness. Clinical treatment with sensitive anti-tuberculosis drugs and regular puncture according to the condition are needed to relieve the symptoms.