The cost of one cycle of targeted therapy for breast cancer: single-targeted therapy costs about 5000-6000 yuan, double-targeted therapy costs about 10000 yuan, different places and different drug manufacturers have different charges, it is recommended to refer to the local hospitals’ charge prices. Targeted therapy for breast cancer is mainly for individuals with overexpression of HER-2 (Human Epidermal Growth Factor Receptor 2) detected by immunohistochemistry, and if the HER-2 test is positive (2+), further FISH test should be done. HER-2 overexpression is present in 20% to 30% of breast cancer patients. Targeted drugs for this gene are trastuzumab and patuximab, and the postoperative adjuvant regimen lasts for one year, with different charges in specific hospitals and localities.