The skull is a very important part of the human skeleton and an important protective barrier for the nerve centers. The skull is located above the crista and consists of 23 flat and irregular bones of different shapes and sizes (the three pairs of auditory ossicles in the middle ear are not included). With the exception of the mandible and hyoid bone, the other bones are firmly connected to each other by sutures or cartilage, which protects and supports the brain, the sensory organs, and the beginnings of the digestive and inhalation organs. However, in reality, some accidents or cranio-cerebral surgeries sometimes cause defects in the bones of the skull, which destroys this protective and supportive role and exposes the brain and intracranial soft tissues to danger. That is why cranial bone repair needs to be done in time. So when is the best time for cranial repair? Generally speaking, if the wound is relatively clean open skull comminuted fracture, no cranial hypertension patients, it is recommended that a one-stage cranial bone repair; for severe closed craniocerebral trauma patients, due to cranial hypertension to remove the large bone flap decompression caused by the huge skull defect, should be about 3 months after the operation for cranial bone repair, the recovery is better can be repaired in advance. Of course, in addition to the timing of repair needs to pay attention to, cranial bone repair materials are also very important. If you choose an inappropriate material, you may have various adverse reactions later. Like some hospitals use titanium mesh material, there are still various problems, some patients will have rejection reaction, resulting in scalp tissue destruction; some patients may occur postoperative infection, some will have scalp cutting injury, ulcers, etc., and titanium mesh is not insulated, postoperative will be very sensitive to hot and cold environments. At present, polyether ether ketone PEEK material is a very advanced and ideal cranial bone repair material, there will be no titanium mesh material with all the problems that occur.PEEK this kind of polymer material due to the material’s biocompatibility is good, able to complex shaping, excellent mechanical properties, good protective properties, postoperative comfort is high, and gradually become the newest trend of cranial bone repair material.