Patients with lung cancer combined with bone metastasis and liver metastasis have poor prognosis, and the survival period is related to many factors, and some studies say that the median survival period is only 8.5 months. Lung cancer is the most common primary malignant tumor of lung, and most lung cancers originate from the mucosal epithelium of bronchial tubes, so it is also called bronchopulmonary cancer. Lung cancer can spread to the surrounding and even the whole body, such as brain metastasis, bone metastasis, liver metastasis, double lung metastasis and so on. Lung cancer combined with bone metastasis and liver metastasis belongs to multiple distant metastasis, which is in advanced stage and has poor prognosis. Lung cancer has a high degree of malignancy, rapid development and poor prognosis, in which the median survival period of non-small cell lung cancer is only 9~10 months, and the 5-year survival rate is less than 5%. According to some studies, the median survival of patients with lung cancer combined with distant metastasis is only 11.7 months, and the overall survival rates of 1 and 2 years are 47.9% and 19.5%; and the prognosis of patients with liver metastasis is the worst, with a median survival of only 8.5 months. The prognosis of patients with multiple metastases was even worse. In conclusion, patients with lung cancer combined with bone metastasis and liver metastasis usually have lost the chance of surgery, so it is recommended to go to regular hospitals to evaluate their conditions and follow the doctor’s instructions to actively cooperate with the treatment, so as to improve the patients’ quality of life and prolong the survival period.