Newborns have pus in the place of vaccination, if it is pus after BCG vaccination may be a normal phenomenon: if it is pus after hepatitis B vaccination, it is considered to be a wound infection, and it is recommended to consult a doctor in time. Newborns vaccinated with pus at the vaccination site, BCG vaccination is usually in the left upper arm, used for the prevention of tuberculosis. Newborns after BCG vaccination, due to their own immune system has not been developed, resulting in poor immunity, the reaction to BCG vaccine is stronger, so the pustules appear after vaccination is a normal physiological phenomenon. If the pustules appear after hepatitis B vaccination, it may be the local skin because of infection, if the scope of infection is small, it is recommended to apply iodine povidone locally to keep the wound clean; if the scope of infection is large, it is recommended to consult a doctor in time. Regardless of the type of vaccine, it is not recommended to poke the abscess, keep the wound clean, disinfect it well, and recommend timely medical treatment.