Long-term medication can bring about a variety of harm to the body, because all drugs have to be metabolized by the liver and kidneys, so no matter what kind of drugs will cause liver and kidney dysfunction. In particular, long-term medication will bring irreversible damage to liver function and kidney function due to the long-term accumulation of drug effects. If you have to take medication for a long period of time, be sure to review your liver and kidney function regularly so that you can adjust the dosage of the medication. Besides, each drug has its own side effects. For example, long-term application of glucocorticoids may cause hyperglycemia, hypertension, and uneven fat distribution as well as osteoporosis and femoral head necrosis. So to try to avoid the appearance of the above side effects, you can apply calcium supplements. At the same time, we should also pay attention to the problem of gastric mucosa, which may cause bleeding and erosion of gastric mucosa, so we can apply acid-suppressing drugs to protect the gastric mucosa.