Waking up in the middle of the night and wanting to vomit is most often associated with gastroesophageal reflux, especially after eating late for lunch, overeating, eating more spicy, greasy, sweet and other stimulating foods, and drinking a lot of alcohol often have similar symptoms. This performance is actually encountered by everyone at one time or another, and there is no need to be too anxious. Adjust your personal habits and diet, and eat less and more often in general. If the symptoms are mild and the attacks are infrequent, you can usually return to normal on your own. In terms of medication, omeprazole and morpholine can be given to inhibit the stimulation of gastric mucosa caused by excessive secretion of gastric acid and promote gastric emptying to reduce esophageal reflux. If accompanied by acid reflux, heartburn, epigastric pain is more obvious, you can give chewable magnesium aluminum carbonate tablets for treatment, to neutralize the effect of stomach acid. If necessary, you can go to the hospital gastroenterology department for relevant examinations, such as gastroscopy or barium meal fluoroscopy. In addition, ultrasound of the liver, gallbladder and pancreas is also needed to rule out diseases of the hepatobiliary system.