“The best four-combination therapy for gastric disease” refers to the four combinations of drugs to eradicate Helicobacter pylori, including proton pump inhibitors (PPI), bismuth and two antibiotics. 1. Proton pump inhibitors: commonly used drugs such as omeprazole and lansoprazole. They are mainly used to inhibit the secretion of gastric acid. 2. Bismuth agent: colloidal bismuth pectin and bismuth potassium citrate are commonly used in clinic, which can block the damage of gastric acid to gastric mucosa. 3. Two antibiotics: according to the patient’s previous medication and allergy history, choose from six drugs: amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin and furazolidone. Quadruple therapy to eradicate H. pylori is the current first-line treatment option, with a 10⁓14-day course of treatment and an eradication rate of more than 90%. If you are diagnosed with this disease, you should seek timely medical treatment, standardize the use of medication, and repeat the examination on time.