Pain can potentially cause hypertension. Pain often causes an increase in blood pressure due to stimulation of the sympathetic nerves, which can cause an increase in heart rate. Hypertension caused by pain is mostly secondary to hypertension, commonly due to pain during surgery and trauma, which can increase the secretion of catecholamines, causing vasoconstriction and increased heart rate, resulting in increased blood pressure. For such patients, it is recommended to give beta-blockers and sedative and analgesic drugs, which can mostly restore blood pressure to normal. In addition, it is important to pay attention to dynamic monitoring of blood pressure changes. For pain-induced hypertension, there are mostly obvious influencing factors. Treatment is firstly directed at the primary cause, and after treatment of the primary cause, hypertension as a secondary symptom can be eradicated or relieved.