Complications and sequelae after total gastrectomy include anastomotic fistula, reflux esophagitis, anemia, malnutrition, and adhesive bowel obstruction. 1. After total gastrectomy, the esophagus and jejunum are anastomosed for digestive tract reconstruction, and anastomotic bleeding or anastomotic fistula may occur after the operation, and if the anastomotic fistula is severe, a second operation may be needed. 2. After total gastrectomy, due to the loss of the pylorus, cardia sphincter contraction, food can easily reflux into the esophagus through the intestines, resulting in reflux esophagitis. 3. After total gastrectomy, iron ions lose their acidic environment, and the absorption of iron ions is affected, thus the synthesis of hemoglobin is affected, resulting in different degrees of anemia. 4. After total gastrectomy, the digestion and absorption of food are affected to different degrees, resulting in malnutrition due to nutrient absorption disorder. 5. The surgical wound of total gastrectomy is relatively large, and there is reconstruction of the digestive tract after the operation, which will cause different degrees of intestinal adhesion and may cause adhesive intestinal obstruction. There are many complications and sequelae after total gastrectomy, so one should pay attention to observation, and if there is any discomfort, one should consult the doctor in time and follow the doctor’s instructions.