With the right choice of indications, ozone injections in patients with lumbar disc herniation will have a more pronounced effect within 1-2 days after surgery, and the patient will get most of the relief from sciatic nerve pain. Ozone injection is a popular minimally invasive treatment for herniated discs over the years. The principle is to inject ozone around the herniated disc, because ozone has a strong oxidizing effect and can dissolve the nucleus pulposus of the herniated disc, thus reducing the pressure on the spinal nerve root and achieving relief of sciatic nerve pain. For the treatment of herniated discs, the ozone method is a better choice. Of course, for more severe disc herniation, especially in patients with calcification of the ligamentum flavum and calcification and hypertrophy of the posterior longitudinal ligament, ozone therapy may not be an effective choice. Therefore, the indications for ozone therapy must be strictly selected, and the patient’s outcome is better when the indications are used correctly.