Osteoarthritis (OA), is a common rheumatic disease. Osteoarthritis ranks 4th in the “list” of diseases affecting women’s health and 8th in the list of diseases affecting men’s health. Currently, about 355 million people in the global population suffer from osteoarthritis, and in Asia, one in six people suffer from osteoarthritis. Due to the intensity of troop training, there is an early onset and multiple incidence. Osteoarthritis (OA) is the result of the interaction of mechanical and biological factors that imbalance the normal progression of synthesis and degradation of articular cartilage cells, extracellular matrix and subchondral bone. The disease occurs not only with damage to the articular cartilage but also involves the entire joint, including the subchondral bone, ligaments, joint capsule, synovium and periarticular muscles, culminating in articular cartilage degeneration, fibrosis, fracture, ulceration and damage to the entire joint surface. Knee osteoarthritis is the most common type of osteoarthritis. Knee osteoarthritis (KOA) is an all-encompassing, multi-level, chronic inflammatory disease with degenerative changes in the articular cartilage at its core, involving the bone and including the synovium, joint capsule and other structures of the joint to varying degrees. At present, due to the lack of sufficient understanding of the etiology and pathogenesis of knee osteoarthritis, numerous links have not yet been uncovered unclear, mainly symptomatic treatment, and research and development of some change course drugs, such as sodium hyaluronate, superoxide dismutase, etc.. Although there are many treatments for KOA, there is no single specific treatment method yet. The effectiveness of acupuncture in the treatment of osteoarthritis is obvious, as reflected by clinical reports in various journals, but there is a lack of research on the scientific basis for the effectiveness of the acupuncture release method in the treatment of osteoarthritis. On the other hand, as a closed procedure, the safety and effectiveness of acupuncture depends on the operator’s subjective knowledge of the disease and proficiency in the anatomical location of the operated site. Therefore, in the process of promoting the application of this treatment method, the chances of side effects and complications are greatly increased, and sometimes irreversible injuries such as tendon rupture, nerve damage, pneumothorax, etc. are produced. In order to improve the safety and efficacy of acupuncture treatment, the development of visual acupuncture therapy is the key. The needle knife release method has formed a relatively complete and standardized treatment method, and has achieved good results. However, there is a lack of basic research on the mechanism of action of the needle knife release method, and the basic research problem of this needs to be solved. On the other hand, the safety of acupuncture surgery has always been a concern. The acupuncture knife is developed from the nine needles of acupuncture, but it is a closed surgery, and its great characteristic is to cut, peel and unblock the lesion under non-visible conditions. Therefore, it requires the practitioner to have very profound anatomical knowledge and high skill in performing the procedure. Therefore, the side effects and complications of acupuncture therapy have been constantly appearing in clinical practice. This has greatly limited the promotion of acupuncture. Research on needle knife visualization is obviously the best way to address the safety of needle knife, and there are few reports on it. Commonly used interventions can use ultrasound, X-ray, CT and MRI, because the needle knife is metal, MRI cannot be used; CT it obviously increases the economic burden of patients, stronger radiation brings harm to both doctors and patients, inconvenient in practice, it can not monitor the operation of the needle knife process in real time, it can only be done by needle feeding – scanning -imaging- then adjusting the way to feed the needle; x-ray can not observe the soft tissue lesions, and needle knife mostly for soft tissue diseases.