Mr. Wang is the president of a private enterprise, nearly 50 years old, always on the move, with the accumulation of wealth, personal energy is not as good as before. The most sad thing for him is that his parents have passed away one after another with malignant tumors in the past two years, which makes him feel anxious at times: he often heard people say that malignant tumors are hereditary, will he also suffer from his parents’ malignant diseases? So, on the recommendation of a “professional”, he spent a lot of money to have PET-CT (Positron Emission Tomography) examination once every six months to eliminate his worries. Is this practice reasonable? How should special people like Mr. Wang arrange for medical checkup? The so-called high-risk groups of tumors are: 1. people with family history of malignant tumors (usually including immediate or collateral relatives within three generations who have suffered from malignant tumors); 2. people with bad habits (long-term heavy smoking, long-term alcohol abuse, drug abuse, long-term overwork, severe malnutrition, partial diet, etc.); 3. people with long-term exposure to toxic and harmful substances due to occupational factors; 4. Polluted people (chemical pollution, heavy metal pollution, nuclear pollution, etc.); 5. People suffering from special microbial infections (hepatitis B virus, HIV, human papilloma virus, Helicobacter pylori infection, etc.). The above high-risk groups in the annual arrangement of physical examination, it is best to find a medical oncologist to do a comprehensive analysis, tailored to a set of physical examination programs suitable for me, as early as possible to find the problem, while avoiding some unnecessary excessive examination. The reason is that PET-CT does not have advantages in early screening of malignant tumors. In clinical practice, PET-CT is usually used for benign and malignant identification of abnormal masses, recurrence of malignant tumors, localization of metastases, staging of malignant tumors and determination of treatment target areas. People with family history of malignant tumors should preferably provide at least three complete family generations with pathology reports of those who have suffered from malignant tumors at the time of consultation, so that oncologists can provide them with tumor risk consultation services and, if necessary, choose whether to conduct corresponding genetic experiments to further make risk assessment of tumor susceptibility and propose risk prevention and control measures, including regular monitoring (reasonable physical examination items), chemoprevention, surgical prophylaxis and surgical resection. ), chemoprevention, surgical prophylactic resection, etc. For example, people with a family history of hereditary colorectal cancer should undergo relevant genetic tests early to clarify whether they are accompanied by specific gene mutations and inheritance, and they should have a full colonoscopy once a year, and once polyps and adenomas are found, they should have a full colonoscopy and polypectomy/adenoma removal once every 6 months. For example, if a long-term heavy smoker has a smoking index of more than 400 cigarettes per year (years of smoking multiplied by the number of cigarettes per day), it is recommended that he or she should undergo at least one digital chest radiograph per year, including frontal and lateral radiographs, and if a suspicious occupying lesion is found, it should be combined with a chest CT scan and fiberoptic bronchoscopy to further If suspicious occupying lesions are found, they should be promptly combined with CT scan and fiberoptic bronchoscopy to further confirm the diagnosis. Long-term alcoholics should have at least one abdominal ultrasound examination every six months, and if abnormalities are found, they should be combined with abdominal CT scan or MRI examination. Drug abuse commonly includes hormone cancer, for example, women who take estrogen for a long time may be induced to breast cancer and should focus on breast examination during physical examination. Long-term use of anti-estrogen tamoxifen may lead to endometrial cancer, so this group of people should focus on gynecological checkups. The third group of people should receive a comprehensive and systematic medical examination every six months, including the blood system, immune system, genitourinary system, digestive system and respiratory system, which are vulnerable to the influence and harm of toxic and harmful substances. At the same time, arrange for no less than 2 weeks of convalescence to allow the body to get out of the bad environment and have the opportunity to recuperate. The fourth group of people should be clearly informed of the pollutants in their living environment during the physical examination, so that the specialist can analyze and investigate and then conduct a targeted physical examination. For example, long-term exposure to combustion emissions and coal tar can easily induce lung cancer and skin cancer, exposure to benzene can induce acute leukemia, exposure to vinyl chloride can easily induce liver tumors, chromium and nickel can easily induce sinus cancer and lung cancer, etc. After confirming the type of pollutants, the way of human exposure, and the length of time, arranging focused and targeted screening can reduce the number of links, improve efficiency, and detect problems as soon as possible to avoid serious consequences. When arranging annual physical examinations for the 5th group, we should first clarify the type of microbial infection and current infection status, and then conduct physical examinations for tumors that are closely related to that microorganism. For example, hepatitis B virus is associated with primary liver cancer, HIV is associated with Kaposi’s sarcoma, human papilloma virus is associated with cervical cancer, and Helicobacter pylori is associated with gastric cancer. The identified microbial infections should be actively treated along with close follow-up to interrupt the chain of tumorigenesis. In conclusion, regular and reasonable medical checkups can detect problems early, nip the development of malignant tumors in the bud as much as possible, and achieve the best treatment effect, while avoiding and reducing a lot of unnecessary waste.