The heart knot always can not be opened may appear the following diseases: 1, there may be depression, the heart knot is always repressed in the bottom of the heart, it is possible to make their own special pain unhappy, every day to taste the pain of the experience will be in a depressed mood, happy, pessimistic about the future, disappointment, feel low self-esteem and even negative thoughts, in the long run there will be the problem of depression. 2, there may be the problem of anxiety disorder Problems, because there are knots always worried, nervous, things repressed in the bottom of the heart, think it is a big secret no way to talk to people, always afraid, anxious, worried, nervous, in the long run will be the problem of anxiety disorders. The above disorders are more common, there may also be symptoms of physical discomfort, and even physical symptoms such as unstable blood pressure, nausea and headache.