Twin transfusion syndrome usually occurs between the 15th and 26th week of pregnancy and has a high probability of fetal death and requires aggressive treatment. Twin transfusion syndrome refers to a serious complication of twin amniotic sacs monozygotic twin fetuses. It is a clinical condition caused by one fetus in the uterine cavity delivering blood to the other fetus, and the fetus with too much blood volume will have excessive amniotic fluid, edema, and cardiac failure, while the fetus with less blood volume will have low amniotic fluid, anemia, and growth restriction. Twin fetal transfusion syndrome mainly occurs in the 15th to 26th week of pregnancy. The disease can be treated by amniotic fluid reduction, selective fetal reduction, fetoscopic laser electrocoagulation and termination of pregnancy, etc. It is recommended that the patient choose the suitable treatment plan under the guidance of the doctor and in conjunction with his/her own situation.