The higher the neuron-specific enolase the greater the degree of likelihood, but not certainty. Neuron-specific enolase is a tumor marker, and if the test results are elevated, it may be due to certain diseases, especially neoplastic diseases such as neuroblastoma, small cell lung cancer, medullary carcinoma of the thyroid, and pheochromocytoma, as this substance has a great deal to do with the progression of the disease. If there is a significant increase in the level of neuron-specific enolase, it is likely to indicate a higher degree of malignancy as well, but it may also be due to some other diseases, such as cerebral infarction, encephalitis, and so on. If malignancy is suspected, it is not possible to rely solely on the results of this one test or one examination, but rather, dynamic observation and other clinical examinations should be combined, and it is recommended to actively cooperate with the doctor to take further examinations to clarify the cause.