A blood creatinine of 320 umol/L is usually indicative of acute and chronic renal failure, among other things. If the patient’s edema is severe and the foot is squeezed by the shoe, he or she may have walking discomfort. If the patient is combined with renal bone disease, foot pain, may also be walking discomfort. 1. Acute renal failure: patients with acute renal failure may have swelling of the lower limbs, wearing shoes is inconvenient, especially in the state of walking, it may be uncomfortable; if the high degree of edema may even cause heart failure, and there will be chest tightness and shortness of breath when walking. 2. Chronic renal failure: Chronic renal failure patients with blood creatinine up to 320umol/L, if combined with renal bone disease, causing bone pain, and in severe cases, there may be bone fracture, and may also be uncomfortable to walk. On the whole, patients with renal failure walking discomfort, in addition to consider related to kidney disease, need to consider whether there is a skeletal or muscular system problems, it is recommended to consult nephrology and orthopaedics in time to find out the cause, and use medication under the guidance of a professional physician.