Glomerulonephritis is a localized immune-inflammatory reaction caused by antigen-antibody complexes deposited on the glomerular basement membrane.The causative agent of acute glomerulonephritis is mainly streptococcus. Streptococcal infections of the respiratory tract or skin can lead to glomerulopathy and acute glomerulonephritis. Other common pathogenic bacteria, such as respiratory syncytial virus, staphylococcus, Klebsiella pneumoniae, etc., invade the organism to appear infections, which are the triggers leading to the recurrence and relapse of chronic glomerulonephritis condition. When patients with glomerulonephritis are found to have infections, they need to clarify the site of infection as well as the causative organisms as soon as possible, and select antimicrobial drugs for treatment in a targeted manner.