E. coli does not normally cause anal itching, but may do so under certain special circumstances. E. coli is a normal parasite of the human intestinal tract, belongs to the opportunistic pathogenic bacteria, usually does not make the human body appear infected, so in general E. coli will not lead to anal itching. However, for diabetes, long-term bedridden and other immunocompromised people, the bacterium has a lower chance of causing perianal skin infection, in the inflammation stimulation can appear around the anus skin itching. In addition, E. coli may cause perianal itching if localized in the perianal area accompanied by a large accumulation of the bacterium or if it causes a serious infection, such as an anal fistula or rectal endoleak. For the majority of the population, itching in the anus should be considered with or without perianal eczema, hemorrhoids, intestinal parasites and fungal infections, it is recommended to consult the dermatology department of the regular hospital in a timely manner, under the guidance of the doctor to further find the cause and take targeted treatment.