The main measures to prevent thrombosis after fibula fracture surgery include basic prevention, physical prevention and drug prevention. 1. Basic prevention: Elevating the affected limb is good for blood reflux, and more ankle pumping exercises can prevent thrombosis. Do more deep breathing or coughing. Keep bowel movement smooth. 2. Physical prevention: Wearing compression stockings or applying pneumatic pressure therapeutic instrument can be beneficial to the blood return of the lower limbs to prevent thrombosis, and take the initiative to do straight leg lifting. 3. Drug prevention: subcutaneous injection of low molecular heparin sodium and oral rivaroxaban under doctor’s guidance. Regular monitoring of blood routine and coagulation function. The above methods are helpful to prevent thrombosis after fibula fracture surgery. Patients should follow the doctor’s instructions to do a good job of related care.