Sertraline taken at night may affect sleep. Sertraline is an antidepressant, a classic 5-hydroxytryptamine reuptake inhibitor, the drug can enhance the concentration of 5-hydroxytryptamine in the brain, there is a certain degree of excitability, some patients may experience insomnia after taking the drug phenomenon, is a common adverse reaction to the drug, but most of the patients in the medication for 2-3 weeks, the adverse reaction will gradually tolerate the symptoms of insomnia has improved. Sertraline should be taken when the drug should pay attention to the drug components of allergy is prohibited, when taking the drug is prohibited and monoamine oxidase inhibitors, after taking the drug if there are serious adverse reactions, such as anorexia, somnolence, insomnia, vertigo, etc., if necessary, need to stop the drug and consult a doctor. The medication should be taken in accordance with the doctor’s instructions to avoid the adverse effects of the drug.