Lumbar disc herniation with severe nerve compression symptoms can be treated with dexamethasone for quick pain relief, but the drug does not work as a cure. Lumbar disc herniation, if the destruction of the annulus fibrosus is serious, resulting in serious dislodgement of the nucleus pulposus and extrusion of the spinal nerve root or cauda equina, severe pain symptoms will occur. Dexamethasone is a hormone drug that can play an anti-inflammatory and analgesic role in a relatively short period of time during the acute attack of lumbar disc herniation. However, dexamethasone is generally not recommended for treatment of lumbar disc herniation when the symptoms are not obvious. Because the prolonged use of dexamethasone will form a certain degree of drug dependence, and may appear gastrointestinal diseases such as gastric ulcers, digestive perforation, etc., may also cause endocrine diseases such as diabetes mellitus. In summary, lumbar disc herniation can be considered in the acute exacerbation of dexamethasone treatment, but is not recommended to be used in remission, it is recommended that patients go to the regular hospital in time, according to the professional doctor’s recommendations for treatment.