High pepsinogen II may be caused by atrophic gastritis, duodenal ulcer, gastric ulcer and so on.
Pepsinogen is the precursor of pepsin, which is clinically divided into two types: type I and type II. The level of pepsinogen in both sera can reflect the morphology and function of the gastric mucosa in different parts of the stomach, among which, pepsinogen II is secreted by gastric fundic gland main cells and mucus neck cells, pyloric gland, cardia gland and duodenal bourethraeic gland, and the elevated value of which may be gastric or duodenal ulcers.
1. Atrophic gastritis: atrophic gastritis may occur due to abnormal autoimmune function, bad life habits, gastric mucosal damage, etc. When patients are tested accordingly, high pepsinogen II will be found.
2. Duodenal ulcer: due to genetic factors, excessive secretion of gastric acid, etc., can lead to the occurrence of gastroduodenal ulcer, which will lead to the phenomenon of high pepsinogen II.
3. Gastric ulcer: due to long-term poor dietary habits and heavy drinking, etc., the gastric mucosa may be attacked by pepsinogen or gastric acid, which will easily lead to ulcer, and the patient will also have high pepsinogen II during the examination.
When pepsinogen II is high, you should go to the hospital in time to clarify the cause of the disease and standardize the treatment under the guidance of the doctor.