There is no such thing as the best cure for cough with phlegm, cough with phlegm may be related to upper respiratory tract infections, bronchitis, asthma, pneumonia and other conditions. Different diseases have different treatments, which can be relieved by medication and other methods. 1. Upper respiratory tract infection: For cough with phlegm caused by upper respiratory tract infection, if the symptoms are mild, no medication can be taken, and general treatment can be given such as attention to rest and drinking more water. If the cough symptoms are more serious, can be given aminobromine, bromhexine and other cough suppressants and phlegm. If there is a basis for bacterial infection, amoxicillin and other drugs can be given. 2. Bronchitis: cough, phlegm and not easy to cough up, can use aminoglutethimide hydrochloride, bromhexine and other drugs. When there is evidence of bacterial infection, new macrolides such as clarithromycin can be used empirically, and cephalosporins such as cefixime or quinolones such as levofloxacin can also be used. 3. Asthma: These patients should first stay away from allergens. At the same time, with the use of budesonide formoterol powder inhaler, montelukast and other medications, if necessary, oral glucocorticoids such as prednisone. If the condition is serious and cannot be relieved by medication, it can also be treated by surgical methods such as bronchial thermoplasty. 4. Pneumonia: for patients with pneumonia, according to the severity of pneumonia, choose oral or infusion treatment, commonly used anti-infective drugs include amoxicillin clavulanic acid, cefixime, levofloxacin and so on. If the cough is more severe, can be given aminoglutethimide to resolve sputum, if necessary, can be given to acetylcysteine nebulization and other methods of treatment. Due to the phlegm cough causes more, if the symptoms do not relieve or aggravate, it is recommended that the patient go to the hospital in time to do a systematic examination, to clarify the cause of the disease, strictly comply with the doctor’s instructions for treatment, do not self-medication.