Diagnostic criteria for hypersplenism include, spleen size, blood changes, blood changes after splenectomy and bone marrow picture.
Abnormal enlargement of the spleen can be observed by subcostal palpation of the size or ultrasound, MRI and other auxiliary examinations.
Blood changes, when hypersplenism, peripheral blood cell reduction, red blood cells, white blood cells, platelets, etc. may appear a single or multiple reductions at the same time.
After splenectomy, the peripheral blood picture can be restored to near or normal level.
Proliferative bone marrow picture, i.e., bone marrow hematopoietic cells are in an active state of proliferation. Reduced blood cell series in the peripheral blood often show significant proliferation in the bone marrow. Some patients may have impaired maturation of blood cells, which is associated with massive destruction of peripheral blood cells, prompting excessive cell release.
Infection, anemia, and perisplenitis may occur in hypersplenism, requiring prompt medical attention to avoid serious complications and, if necessary, splenectomy.