Due to individual differences, there is no absolute safest and most effective long-acting antihypertensive drug, and you need to choose the most suitable drug for yourself under the guidance of your doctor and in combination with your own situation. At present, the commonly used antihypertensive drugs in clinical practice include beta-blocker metoprolol, bisoprolol, etc.; calcium channel blocker nifedipine, verapamil, etc.; angiotensin II receptor blocker valsartan, etc.; angiotensin-converting enzyme inhibitor captopril, etc.; and diuretic hydrochlorothiazide. All of these antihypertensive drugs can effectively reduce blood pressure, control blood pressure levels, and reduce the probability of cardiovascular accidents and myocardial infarction. However, due to individual differences, the drug is not absolutely the safest and most effective, it is recommended to follow the doctor’s instructions combined with their own conditions, the emergence of adverse reactions to timely consultation, drug allergy is prohibited.