castleman disease, also known as giant lymphadenopathy, is a disease that is intermediate between benign and malignant neoplasms. The etiology is unclear, but the main clinicopathological change is reactive hyperplasia of lymph nodes caused by chronic inflammatory cell stimulation. castleman’s disease is clinically classified into clear vascular, plasma cell and mixed types. The most prominent feature is the huge lymph node masses in the abdominal and thoracic cavities, sometimes accompanied by fever, emaciation, night sweats and other symptoms of generalized hypermetabolism. After the diagnosis of cadtleman’s disease, if it can be surgically removed, try to surgically remove it; if surgery cannot be completely removed, the preferred treatment is chemotherapy, which can be treated with the chop program. In recent years, drugs such as lenalidomide and reactive stop can also be applied, because these drugs can inhibit the proliferation of tumor blood vessels.