Widening of the aortic sinus is a pathology that may be associated with aortic atherosclerosis and hypertension, and can be controlled with lipid-lowering drugs or antihypertensive drugs. Widening of the aortic sinus does not usually cause clinical symptoms and does not usually have a serious effect on the patient. However, if the blood pressure of hypertensive patients is not well controlled, or patients with aortic atherosclerosis and other diseases, the widening of the aortic sinus may occur, and should actively take antihypertensive drugs, lipid-lowering drugs for control. Patients with high blood pressure should take the antihypertensive drugs such as Irbesartan and Spironolactone on time to control their blood pressure, and should pay attention to keeping emotional stability, sufficient rest, combining work and rest, and eating a light diet with less oil and salt. Patients with aortic atherosclerosis can take statin lipid-lowering drugs such as lovastatin to relieve, usually eat a light diet, reduce caffeinated beverages, so as not to affect the recovery of the disease. If there is widening of the aortic sinus, timely consultation, identify the cause of the disease, and then targeted drugs and follow the doctor’s instructions to take drugs, so as not to delay the condition.