Parkinson’s disease is a relatively complex disease. There are also many drugs for treatment, so for ease of memory, the drugs are sorted out here. 1. Dopamine drugs: There are two main types: (1) Medopa (Madopar): It is a mixture of levodopa and benserazide in a 4:1 formula. The most appropriate daily dosage of Medopar must be determined according to the conditions of different patients. The following dosage chart can be used as a basic reference.1. The first recommended dosage for initial treatment is 1/2 tablet per interval, three times daily. Subsequent daily doses should be increased by 1/2 tablet per week. Until the amount of treatment appropriate for the patient is reached. (2) Sinemet controlled-release tablets (Sinemet-CR): It is a controlled-release tablet of levodopa and methyldopa hydrazide complex, which can make levodopa blood concentration more stable and reach more than 4-6 hours, which is helpful to reduce the end-of-dose phenomenon, switching phenomenon and peak dose hyperactivity of levodopa. The initial dose for patients who have never received levodopa therapy is 1 xinine controlled-release tablet 25/100 twice daily. In patients requiring larger amounts of levodopa, a dose of 1-4 tablets 25/100 twice daily is well tolerated. 2. Dopamine agonists: There are also two types: (1) Trastal: It can be used as a single drug, especially for the treatment of patients with tremor as the main symptom. It can also be used in combination with levodopa as initial or late treatment. For the treatment of Parkinson’s disease, the dose should be gradually increased, with a maintenance dose of 150mg-250mg per day in divided doses and with meals for treatment alone. When combined with levodopa, the maintenance dose is generally 1-3 tablets per day. (2) Senflor (Pramipexole): It is a new generation non-ergot dopamine agonist, the starting dose is 0.375mg per day, taken orally, swallowed with water, with or without food. Three times a day. If further dose increase is needed, the dose should be increased once a week on a weekly basis, with each daily dose increasing by 0.75mg, to a maximum daily dose of 4.5mg. 3. Anticholinergics – Antan: For patients with early mild disease, with some effect on tremor and muscle rigidity. Commonly used drug is Antan, oral 2-4mg, 3 times a day. Side effects include dry mouth, blurred eyes, absence of sweating, flushing, nausea, insomnia, constipation, urinary retention and, hallucinations and delusions. They disappear with discontinuation and dose reduction. Contraindicated in persons with glaucoma or prostatic hypertrophy. In the elderly, it can cause mental retardation. For patients over 60 years of age, it is now more advocated not to use. 4, amantadine: can promote the release of dopamine, and has a mild agonistic effect on dopamine receptors. 100mg once, 1-2 times a day, the dose is 400mg a day. the effect is better for mild disease, this drug has small side effects. 5.Monoamine oxidase-B inhibitor: Dopamine is oxidatively degraded in the brain by MAO-B and a large number of oxygen free radicals are generated during its metabolism to damage neurons. Therefore, inhibiting the activity of MAO-B can both prolong the residence time of dopamine in the brain, enhance the therapeutic effect, reduce the dosage of levodopa and its side effects, and indirectly play a role in protecting neurons. The commonly used drug Midodopy (Slegiline). It can be taken alone for the treatment of early Parkinson’s disease, or in combination with levodopa/peripheral dopa decarboxylase inhibitors. The starting dose of both is 5 mg, taken in the morning, and the dose of this drug can be increased to 10 mg/day (once in the morning or in 2 separate doses). If the patient develops levodopa-like side effects when combining levodopa preparations, the dose of levodopa should be reduced. 6.COMT inhibitor (entacapone): This drug can stabilize the concentration of levodopa in blood, thus reducing its dose and its side effects. It can prolong the half-life of levodopa and prevent or delay the appearance of motor fluctuations and “isokinetic” phenomena, and should be taken simultaneously with levodopa/benserazide or levodopa/carbidopa. This product may or may not be taken with or without food. Give 0.2 g (one tablet) of this product with each dose of levodopa/dopa decarboxylase inhibitor. The maximum recommended dose is 0.2 g (one tablet) 10 times a day, or 2 g of this product.