The efficacy of epilepsy surgery depends on whether the epileptogenic zone is completely removed. Therefore, the accurate localization of the epileptogenic zone becomes a critical issue. The localization of the epileptogenic zone currently relies on a combination of diagnostic tools for assessment. These include epilepsy history, symptomatic features of seizures, neuropsychological examination, general scalp EEG, audio-visual EEG, magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), PET, SPECT, and magnetoencephalography. Invasive EEG is also performed when necessary, including long-range monitoring with intracranial buried electrodes and intraoperative cortical EEG. The reason for so many examination methods is that no single method can determine the location of the epileptogenic zone with 100% certainty. However, the combined application of multiple examination methods can significantly improve the accuracy of epileptogenic zone localization diagnosis and thus improve the surgical efficacy.