Penile erectile dysfunction can be treated with medications such as phosphodiesterase type 5 inhibitors and prostaglandin enhancer gel. Type 5 phosphodiesterase inhibitors (sildenafil, tadalafil, vardenafil, etc.) are commonly used in the treatment of penile erectile dysfunction, which specifically inhibit the phosphodiesterase activity in the corpus cavernosum of the penis and maintain high levels of cyclic guanosine phosphate in the smooth muscle cells, which in turn leads to the achievement and maintenance of an erection. Adverse manifestations such as facial flushing, dyspepsia, and headache may be present with this class of drugs. Prostaglandin Enhancer Gel is a topical medication for the treatment of erectile dysfunction. The mechanism of action of this class of drugs is to cause smooth muscle relaxation and vasodilatation through penetration of the skin and ultimately into the corpus cavernosum, thereby inducing and maintaining penile erection. A common adverse reaction to this class of drugs is pain in the reproductive system. It is recommended that the medication be used under the guidance of a doctor to avoid improper use of the medication.