Patients with atrophic gastritis but without Helicobacter pylori infection can be intervened with dietary modification, medication, and endoscopic therapy. 1. Dietary regulation: patients with atrophic gastritis have long-term damage to the gastrointestinal mucosa, which can be regulated by diet, such as eating light, easy-to-digest foods, such as millet porridge, noodles, egg custard, etc.; try to avoid spicy and stimulating, greasy food, to reduce the stimulation of the gastric mucosa. 2. Drug therapy: patients with atrophic gastritis can be treated with drugs, such as omeprazole, rabeprazole, etc., which can inhibit the secretion of gastric acid and reduce the stimulation of the gastric mucosa; pectin bismuth, aluminum sulfate, etc., which can also be used to protect the gastric mucosa. 3. Endoscopic treatment: patients with atrophic gastritis may be accompanied by heterotrophic hyperplasia, and patients with severe heterotrophic hyperplasia can be treated with endoscopic treatment. Patients with atrophic gastritis are advised to go to the hospital in time, follow the doctor’s advice for treatment, and have regular follow-ups to avoid delays. The above drugs need to be used under the guidance of a doctor, not unauthorized use of drugs.