Adrenal metastasis of liver cancer can be treated by surgical treatment, chemotherapy, radiotherapy and targeted therapy. Primary liver cancer is one of the common digestive system tumors in China and one of the malignant tumors with the highest mortality rate. Common metastasis modes are intrahepatic metastasis, lymphatic metastasis, blood line metastasis and direct invasion, and common sites include lungs, bones, adrenal glands and brain. Liver cancer patients will have metastasis in the late stage, and when the tumor cells have metastasized to the adrenal gland, it usually indicates that it is already in the late stage, and the chance of radical surgery is usually lost. At this time, comprehensive treatment is usually adopted. Patients should first consider treatment by surgical removal of the adrenal gland. After the surgery, chemotherapy is used to kill the cancer cells to the maximum extent, such as through the use of cyclophosphamide, adriamycin and other drugs to carry out chemotherapy; some patients also need to undergo radiation therapy after chemotherapy. If patients have poor physique and cannot undergo surgery, they can be treated with chemotherapy plus local radiotherapy or chemotherapy combined with targeted therapy, which can effectively alleviate the development of patients’ condition and prolong their survival time. When adrenal metastasis occurs in liver cancer, patients should be diagnosed and treated in time to avoid aggravation of the disease and affecting life expectancy.