Primary Focal Segmental Glomerulosclerosis is generally incurable, but it can be relieved by standardized active treatment to slow down the process of disease development. Primary focal segmental glomerulosclerosis is usually caused by viral infection, genetics and other factors that lead to epithelial and endothelial cell damage, as well as abnormal function of the mesangial cells, thus causing focal segmental glomerulosclerosis, and the pathologic examination can see segmental scarring in some glomeruli, which is clinically characterized by large amount of proteinuria and nephrotic syndrome (NS). At present, there is no clinical cure for primary focal segmental glomerulosclerosis, but patients can be treated with prednisone acetate, methylprednisolone, cyclophosphamide, cyclosporine and other drugs under the guidance of doctors, which can slow down the speed of glomerulosclerosis to a certain extent and slow down the process of disease development. It is recommended that patients with primary focal segmental glomerulosclerosis should consult a doctor in time and actively cooperate with the doctor to standardize the treatment, and at the same time, they should pay attention to rest, avoid anxiety, and maintain a good state of mind.