Depression is a type of mental and emotional disorder characterized by significant and persistent depression due to various causes. Diabetic depression refers to depression that occurs as a result of having diabetes. In recent years, it has been found that the incidence of depression in diabetic patients is significantly higher than that in non-diabetic patients: foreign studies have found that the prevalence of depression in type 2 diabetic patients ranges from 21.8% to 60.0%, which is 3-5 times higher than that in the general population; domestic statistics also show that the prevalence of depression in type 2 diabetic patients ranges from 26% to 38%. Of note is that the rate of depression recurrence in diabetic patients is 8 times higher than in non-diabetic patients, with 64% of diabetic patients having had a depressive episode in the past year and the average number of recurrences per patient during the 5-year follow-up period was 4.2. The occurrence of depression in diabetic patients can make it difficult to control blood glucose, seriously affect the quality of life of patients and their families, and even lead to some tragedies, which should cause us to pay great attention. What causes the increased incidence of depression in diabetic patients? 1, diabetes is a chronic long-term disease, there is no complete cure, patients must always pay attention to diet management, frequent monitoring of blood sugar, long-term medication, some patients need long-term insulin injections, these have greatly reduced the quality of life of patients, and patients generally believe that the use of insulin heralds a serious condition, so these patients have more psychological pressure and pessimism; 2, diabetes Patients with poor glycemic control may develop complications within 5-10 years, which is a constant threat to patients and is bound to cause fear, pessimism and anxiety; 3. Long-term treatment generates a large amount of medical expenses, which brings a heavy financial burden to patients and families, and also causes them serious psychological stress. Cortisol is hypersecreted when diabetic patients suffer from depression. A large amount of cortisol can reduce the utilization of glucose and antagonize insulin, making blood sugar higher and making it more difficult to control. What factors are associated with the development of depression in diabetic patients? Studies by Chinese scholars have shown that gender, age, disease duration, HbA1c, and number of complications are closely related to the incidence of depression in diabetes. The risk of developing depression is 1.7 times higher in women than in men because of their greater mood swings. Many stresses in life, such as work status and income, combine to affect the psychological state of diabetic patients. Middle-aged people bear the pressure from family, society and life in society, so the prevalence of depression is higher in the middle-aged group than in other age groups. Similarly patients with longer duration of diabetes and more complications have relatively more mental and economic stress and higher prevalence of depression. Therefore, in order to better improve the quality of life of diabetic patients, it is important to pay special attention to the combination of depression and other psychological disorders in women with long duration of disease, many complications and poor long-term glycemic control and to treat them promptly. The main clinical manifestation of diabetes mellitus combined with depression is depressed mood, which is not proportional to the surrounding situation, and can range from sullenness to grief, and even wood stiffness; some cases have obvious anxiety and motor agitation, and serious cases may appear hallucinations, delusions and other psychotic symptoms. Some elderly patients may experience severe insomnia, constipation, bloating, decreased appetite, increased heart rate, increased blood pressure, anterior heart pain, and pain-based symptoms such as headache, low back pain, and joint pain, and pain medication is not helpful. When family members or doctors notice these conditions in patients with diabetes, they should be alert to the occurrence of diabetic depression. The treatment of depression in diabetes is divided into two aspects: psychological intervention and pharmacological treatment. Psychological intervention can enhance the patient’s confidence, eliminate doubts and worries, greatly improve the patient’s psychological condition, effectively reduce the patient’s pain, improve confidence in curing the disease, and improve the quality of life. For patients with milder conditions, family members and endocrinologists can make psychological interventions for patients: first, let patients learn more about diabetes, let them understand that as long as they can control their blood sugar better, they can slow down or even avoid complications, and with the development of science and technology, there will be more convenient and effective methods to treat or even cure diabetes, and all they need to do now is to adjust their physical condition to the best and wait for the arrival of new methods. For now, all you need to do is to adjust your health to the best condition and wait for the arrival of new methods; in addition, you should let the patient live in a relaxed and happy environment and chat with him or her often to try to divert his or her excessive attention from diabetes. For patients with more serious conditions, family members should visit the psychology department in time, and psychologists will use more professional methods to psychologically intervene with patients. The pharmacological treatment of diabetic depression is divided into symptomatic treatment and antidepressant treatment: for some patients with constipation and insomnia, symptomatic treatment can be given to promote gastrointestinal motility and small doses of valium or even placebo; antidepressant drugs tricyclic drugs and selective 5-hydroxytryptamine inhibitors, tricyclic drugs can cause hypoglycemia and hyperglycemia, the current application has been less, 5-hydroxytryptamine inhibitors can improve depression and blood sugar, independent of age, obesity and renal function. 5-serotonin inhibitors can improve depression and blood sugar, independent of age, obesity and kidney function, and have fewer side effects, and can be used as the first antidepressant for diabetes, whose representative drug is Prozac. However, the use of these drugs must be purchased and taken under the guidance of a medical professional. Diabetic depression is quietly happening around us, let’s pay attention to diabetic depression together, reduce the psychological pressure of patients, improve the quality of life of patients and avoid tragedies.