Usually, the interferon used to treat thrombocytosis is recombinant human interferon alpha-2b injection. Interferon is a kind of cytokine, which has various effects such as inhibiting cell division, regulating immunity, anti-virus, anti-tumor and so on. Because interferon can inhibit megakaryocyte production and shorten platelet survival time, interferon is also widely used in the treatment of thrombocytosis. Recombinant human interferon alpha-2b injection has some contraindications for clinical application, such as those with known hypersensitivity to interferon products, those with a history of angina pectoris myocardial infarction as well as other serious cardiovascular diseases, those with other serious diseases that cannot tolerate the side effects of the product, and those with epilepsy and other central nervous system dysfunction. The more common adverse effects of the drug are fever, fatigue, arthralgia, and lack of appetite. Therefore, it is recommended to use the drug under the supervision of a doctor. In the course of treatment, patients must follow the doctor’s instructions for medication, regular follow-up review, timely grasp of the changes in the condition, timely adjustment of the treatment program.